Change in Patient Enrollment After Site Principal Investigator Turnover in Surgical Clinical Trials.

Results from the segmented regression, although not statistically significant, suggested a decreasing trend in patient enrollment before site PI turnover and an immediate decrease after turnover; the estimates for the preturnover trend, turnover quarter, and postturnover trend were −0.25 ( P = .15), −1.37 ( P = .26), and 0.39 ( P = .29), respectively ( Figure ).

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