We then compared T21 over D21 log 2 FC expression changes with the combined (+dox and w/d) XIST correction, which revealed a highly significant and negative Pearson correlation of −0.65 ( Fig. 3C , right) that persists even when chr21 genes are excluded (fig.
← all excerpts
A dynamic in vitro model of Down syndrome neurogenesis with trisomy 21 gene dosage correction.
1
—
—