C3d-Targeted factor H inhibits tissue complement in disease models and reduces glomerular injury without affecting circulating complement.

Furthermore, we found a highly significant correlation (Spearman’s r = 0.76; p < 0.00000001) between uC5b-9/uCre and tissue glomerular C3 fragment deposition, measured by anti-C3 fragment immunostaining ( Figure S13 B), suggesting that uC5b-9/uCre is a urine biomarker of kidney tissue complement activation.

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