SubSol-HIe is an AMPK-dependent hypoxia-responsive subnucleus of the nucleus tractus solitarius that coordinates the hypoxic ventilatory response and protects against apnoea in mice.

This aforementioned findings may be significant given that while AMPK-α1/α2 deletion attenuated increases in sigh frequency, because a few carotid body chemoafferent terminals project to 10N [ 25 ], hypoxia has been found to increase sigh frequency in a manner dependent on vagal in addition to carotid body chemoafferent activity [ 7 ].

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