Sarcoma_CellminerCDB: A tool to interrogate the genomic and functional characteristics of a comprehensive collection of sarcoma cell lines.

For example, when expression of the erythroblast transformation specific (ETS) family transcription factor FLI1 is plotted against the expression of SLFN11 or CD99 (encoding a cell surface and T cell adhesion glycoprotein) in the full sarcoma cell line panel, the scatterplots reveal highly significant correlations between FLI1 and both SLFN11 and CD99 expression in the majority of Ewing sarcoma cells, which is consistent with known disease biology ( Figure 2 C, left and middle panels). 16 , 18 Importantly, even in subtypes with fewer available cell lines, the Univariate Analysis tool can identify distinct biological features characteristic of those subtypes.

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