highly significantp<0.001
We observed both one-sided and two-sided PO to correlate with a highly significant increase of disease duration (regression coefficient 2.39 [95% CI, 1.93 to 2.83], p<0.001 and regression coefficient 4.27, [95% CI, 3.80 to 4.75], p<0.001, respectively) ( table 2B and figure 1 and online supplemental table 3B ).