Impact of low-level exposure to antibiotics on bile acid homeostasis in adults: Implication for human safety thresholds.

A two-sided q value of < 0.05 was considered to be statistically significant and 0.05 ≤ a two-sided q value ≤ 0.01 was considered to be marginally significant.

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Some bile acid ratios showed a decreasing trend by categorized EDED of five antibiotic categories and the number of bile acid ratio showing a decreasing trend ranged from two (DCA/CA and UDCA/GUDCA for quinolones) to eight (all bile acid ratios for macrolides) ( Fig. 2 ).

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