Sample-Treatment with the Virucidal β-Propiolactone Does Not Preclude Analysis by Large Panel Affinity Proteomics, Including the Discovery of Biomarker Candidates.

This result is of great potential interest, as the PRECOG data set 12 indicates a highly significant association ( z -score = 6.40) of COL10A1 gene expression with a short survival in ovarian cancer, which is consistent with the reported association of COL10A1 with other cancer entities. 21 − 23 Conclusion In conclusion, the BPL treatment of different sample types does not appear to significantly and globally impact the detection of differential protein expression using affinity proteomic workflows, such as SomaScan and Olink Target.

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