Loss of CFTR Reverses Senescence Hallmarks in SARS-CoV-2 Infected Bronchial Epithelial Cells.

In particular, SARS-CoV-2 infection led to an increasing trend of p21-IR cells in WT cells at all time points analyzed, while a decreasing trend of p21-IR cells was observed in CFTR KO cells at all time points analyzed (except at 3 h), suggesting a different impact of SARS-CoV-2 infection in the two cell lines ( Figure 3 C).

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