Premature thymic functional senescence is a hallmark of childhood acute lymphoblastic leukemia survivorship.

Premature thymic aging in cALL survivors To determine the normal rate of T-cell compartment immunoaging we measured blood TREC levels normalized to the T-cell count in the Quebec reference population and observed a highly significant correlation with chronological age for both men and women (Pearson correlation: males, r = −0.466; females, r = −0.504; p < 0.0001) (Fig. 1A , controls).

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Hypothyroidisms was associated with an increasing trend in thymic aging, revealed by decreased TREC levels and increased immunoage gain (Supplementary Fig. 3C, D ).

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