Invasive vs. conservative management of older patients with non-ST-elevation acute coronary syndrome: individual patient data meta-analysis.

Applying a fixed-effect approach to our primary analysis reproduced similar results except from the composite endpoint, for which the fixed-effect Cox model yielded an almost significant result in favour of the invasive strategy ( Supplementary data online , Figure S2 and Appendix p 23).

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There was no statistically significant difference in the hazard for our primary endpoint using random-effects Cox modelling, but the hazard of all-cause mortality and reinfarction did reach borderline significance with fixed-effect Cox modelling.

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