Integrative genomic analyses of European intrahepatic cholangiocarcinoma: Novel ROS1 fusion gene and PBX1 as prognostic marker.

To classify iCCA transcriptomic dysregulation in the context of cancer hallmarks, we performed gene set enrichment analysis (GSEA) and observed a highly significant enrichment of MYC targets among the upregulated genes (Figure 3B, C , Table S13A ), confirming the involvement of c‐MYC in cholangiocarcinogenesis. 63 Furthermore, the enrichment of E2F and G2M checkpoint genes reflects proliferative activity.

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