Characterizing molecular and synaptic signatures in mouse models of late-onset Alzheimer's disease independent of amyloid and tau pathology.

Aβ40 was lower in males fed a HFD at 12 and 18 months, but the same difference was not observed in females; Aβ42 levels were not significant at any time point, likely due to variability among groups, however, there was an overall trend for a reduction in Aβ42 in males fed a HFD at 12 and 18 months (Figure 5D,E ).

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