A new reagent for in vivo structure probing of RNA G and U residues that improves RNA structure prediction alone and combined with DMS.

Beginning with U, almost all these mutation signatures, including the three single-nucleotide mismatches, showed highly significant increases in background-subtracted mutation rates between paired and unpaired residues, with median fold changes of 1.1–1.3 for T to A, T to G, and T to C, suggesting that they were informative of pairing state ( Fig. 6 A; Supplemental Fig.

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