While animals from both genotypes reduced their urine K + concentrations and total daily urine K + excretion on the 0 K diet, both parameters remained higher in Kir4.2 −/− mice compared to controls, although differences did not achieve significance by post-hoc testing (Fig. 1e, f ).
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Low potassium activation of proximal mTOR/AKT signaling is mediated by Kir4.2.
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