an increasing trendp = 0.0052
We then quantified the relative abundance of the cells in each cell state throughout the aging process and found that the number of State 1 cells kept decreasing with age and that of the State 4 cells showing an increasing trend (State 1: p = 0.0052; State 2: p = 0.73; State 3: p = 0.72; State 4: p = 0.05).