The Lectin Pathway-A Dominant Pattern of the Complement System Activation in Primary Focal Segmental Glomerulosclerosis?

2 In the univariate logistic regression models, IgM positivity (69% of samples) and C3 positivity (17% of samples) were not associated with treatment failure, which is defined as nonachievement of at least partial remission at the last follow-up, (odds ratio [OR]: 2.35, 95% confidence interval [CI]: 0.71–7.87, P = 0.164 and OR: 1.53, 95% CI: 0.39–5.99, P = 0.545, respectively), percentage of SSG was marginally significant (OR: 1.03, 95% CI: 0.99–1.07, P = 0.088), whereas percentages of interstitial fibrosis and tubular atrophy and percentage of C4d+ nonglobally sclerosed glomeruli were independent predictors of treatment failure, and remain significant after the adjustment to the 24-hour proteinuria and percentage of SSG in the multivariate model (OR per 1% = 1.06, 95% CI: 1.003–1.11, P = 0.038 and OR per 1% = 1.03, 95% CI: 1.007–1.054, P = 0.008, respectively).

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