Efficient production of guanosine in Escherichia coli by combinatorial metabolic engineering.

MG1655 Δ lacI and MQ4 accumulated 8.1 mg/L and 10.9 mg/L of hypoxanthine after 24 h of fermentation, respectively, and the amount of hypoxanthine still showed an increasing trend.

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p value < 0.05 (*) was defined as statistical difference; p value < 0.01 (**) was defined as significant; p value < 0.001 (***) was defined as highly significant; ns was defined as no significant difference.

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