3 The largest, most influential cardiac surgery RTTT had a highly significant qualitative interaction in which younger subjects benefited from, whereas older subjects did worse with, a liberal transfusion trigger. 5 Because we could not adequately account for such an interaction in our meta-analysis, we prospectively excluded cardiothoracic surgery trials.
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Risks of Restrictive Versus Liberal Red Blood Cell Transfusion Strategies in Patients With Cardiovascular Disease: An Updated Meta-Analysis.
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