Compared to histamine-2 receptor antagonist, proton pump inhibitor induces stronger oral-to-gut microbial transmission and gut microbiome alterations: a randomised controlled trial.

3–7 While both medication classes have proven efficacy in treating acid-related conditions, there has been a notable trend of prolonged usage of PPIs being more associated with an increased risk or progression of bowel diseases like colorectal cancer (CRC) and IBD, as well as pneumonia and enteric infections like Clostridium difficile infection. 5 6 8–10 On the other hand, H2RAs are widely considered to be a safer alte

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