Barely Significant
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Burden of drug use disorders in the United States from 1990 to 2021 and its projection until 2035: results from the GBD study.

BMC Public Health · 2024 · PMC11188227 · PMID 38898398

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a decreasing trendno p-value reported
Regardless of gender, the burden of DUDs is highest in the age-specific groups of 15–45 years and showed a decreasing trend with age, which was consistent with the world pattern.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.