Understanding the burden of antibiotic resistance: a decade of carbapenem-resistant Gram-negative bacterial infections in Italian intensive care units.

Over the years, a decreasing trend was observed for carbapenem-resistant Klebsiella species for VAP ( p -value < 0.001) and UTI ( p -value < 0.003), while the trend was not significant for BSI ( p -value = 0.134) and IAI ( p -value = 0.018).

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Data from the ECDC latest surveillance report ( European Centre for Disease Prevention and Control, 2022 ) showed indeed an increase in the population weighted mean MDR percentage over the period 2018–2022 and an increasing trend in infections caused by CRPA and carbapenem-resistant Klebsiella and Acinetobacter spp.

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