Even though this effect became borderline significant after FDR correction, sPLS-DA analysis demonstrated clusters of parameters (i.e., mostly VLDLs in Component-1 and HDLs in Component-3) being differentially regulated in the participants with and without the H202D variant (Fig. 7d ).
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Total and H-specific GDF-15 levels increase in caloric deprivation independently of leptin in humans.
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