Isoflurane anesthesia and sleep deprivation trigger delayed and selective sleep alterations.

During P-IA on day1, 6 out of 7 mice showed an increasing trend in Wake percentages from Baseline1.

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The two baselines did not show significant differences in the total percentage of Wake, NREMS and REMS though 5 out of 7 mice showed a decreasing trend from Baseline1 to Baseline2 in the percentages of REMS during the light period (Fig. 1 a) and in the percentages of wakefulness (Wake) during the dark period (Fig. 1 b).

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