Tumor-stroma contact ratio - a novel predictive factor for tumor response to chemoradiotherapy in locally advanced oropharyngeal cancer.

We observed that higher TSC correlated strongly with poorer outcomes and was highly significant with regard to disease progression when dichotomized at the median (median OS: 13 months vs 136, p < 0.0001 and median PFS: 5 months vs 85 months, p < 0.0001) ( Fig. 4 A and 4 B). p16-positive OPSCC have a proportionally smaller tumor stroma contact surface compared with p16-negative OPSCC We observed that the TSC was significantly higher in p16-negative OPSCC as compared to their p16-positive counterparts.

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