TOMM40 and APOC1 variants differentiate the impacts of the APOE ε4 allele on Alzheimer's disease risk across sexes, ages, and ancestries.

Alzheimers Dement (Amst) · 2024 · PMC11193136 · PMID 38912305

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highly significantp = 1.50 × 10 −9actually significant

These differences underscore a highly significant excess in AD risks for the higher‐risk CompGs compared to the lower‐risk CompGs in NHWs, for example, 59% ( p = 1.50 × 10 −9 ) for the 1XY+2XY CompG.

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&lt;i&gt;TOMM40&lt;/i&gt; and &lt;i&gt;APOC1&lt;/i&gt; variants differentiate the impacts of the &lt;i&gt;APOE ε&lt;/i&gt;4 allele on Alzheimer's disease risk across sexes, ages, and ancestries.

The sentences

<i>TOMM40</i> and <i>APOC1</i> variants differentiate the impacts of the <i>APOE ε</i>4 allele on Alzheimer's disease risk across sexes, ages, and ancestries.