Monthly treatment with romosozumab for 1 year increases bone mineral at the hip, but not the knee, in women with chronic spinal cord injury.

A previous 5-yr longitudinal bone evaluation in individuals with chronic SCI and no treatment indicated a nonsignificant trend toward improvement in spine and hip aBMD, but a trend toward loss of distal femur and proximal tibia aBMD. 50 Thus, in chronic SCI, bone mineral at the lumbar spine and hip is better conserved than at the knee, even without treatment.

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