highly significantp=2.30×10 -25
Of note, a recent study reporting a highly significant genetic correlation between endometriosis and migraine (r g =0.38, p=2.30×10 -25 ) also implicated TRIM32 as an overlapping gene between the two disorders. 37 The role of TRIM32 as a potential risk variant in migraine, CTS, and endometriosis is yet unclear and requires further study, though it is intriguing to note its association with three disorders that predominantly affect females. 38 – 40 The notion of migraine as a peripheral nerve disorder remains debatable, as it conflicts with longstanding theories of central generation of migraine.