WHAT IS NEW HERE ✓ Lysosome-related prediction model is capable of discriminating between good and poor survivors of hepatocellular carcinoma, P values were highly significant. ✓ Elevated RNF19B expression within the cancer cell nests was linked to unfavorable prognostic outcomes and showed a connection with specific clinicopathological characteristics, suggesting its potential significance for assessing the prognosis of patients with hepatocellular carcinoma. ✓ Moreover, it was observed that RNF19B could facilitate the transformation of monocyte-derived macrophages into M2-polarized macrophages and showed a significant positive correlation with PD-1 and CTLA-4.
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Lysosome-Related Genes and RNF19B as Prognostic Markers for Survival and Immunotherapy Efficacy in Hepatocellular Carcinoma.
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