Quantitative estimates of the regulatory influence of long non-coding RNAs on global gene expression variation using TCGA breast cancer transcriptomic data.

(Note: the same lncRNA, paired with the TF, may be significant for more than one target gene, and the same target gene may have more than one interaction terms involving the same TF.) (XLSX) S10 Table Frequency with which each TF appears among significant lncRNA-TF interaction terms.

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While this threshold of 20% is somewhat arbitrary, it does represent a highly significant level of statistical association: a corresponding null distribution estimated empirically by permuting the expression levels of target genes across samples revealed that none of the 11,531 target genes can be modeled at a level better than this threshold ( Fig E in S1 Text ).

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