When all patients in the cohort were dichotomized according to age at diagnosis, the association between thrombosis and DTA mutation was of borderline significance in both age groups (≥60 years OR: 2.44, p = 0.064; <60 years OR: 2.89, p = 0.065).
This association was age independent and, despite the intimate relationship between DTA mutations and CVRF, was an additional risk factor for hypertensive patients. 15 The majority of events were arterial and the association between arterial thrombosis with DTA mutations was significant while only marginal significance was found between DTA mutation and venous thrombosis.