Reduced Insulin Resistance and Oxidative Stress in a Mouse Model of Metabolic Syndrome following Twelve Weeks of Citrus Bioflavonoid Hesperidin Supplementation: A Dose-Response Study.

Hesperidin supplementation in HFSS-fed mice did not significantly affect leukocyte subpopulations, but there was a notable trend ( p = 0.07 and 0.06), where higher doses appeared to reduce elevated macrophage levels (F480 + ) ( Figure 5 and Figure 6 ). 4.

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