Improved Immunotherapy Outcomes via Cuproptosis Upregulation of HLA-DRA Expression: Promoting the Aggregation of CD4⁺ and CD8⁺T Lymphocytes in Clear Cell Renal Cell Carcinoma.

Consistent with the above-mentioned results, it was found that HLA-DRA was positively correlated with the expression of all three genes (PD-1, PD-L1, and CTLA4), and the correlation between HLA-DRA, PDCD1, and CTLA4 in terms of co-expression was highly significant among all six CRGs ( Figure 1 E).

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