Higher serum free thyroxine levels are associated with increased risk of hip fractures in older men.

20 In the MrOS-US cohort ( n = 1817, mean age 74 yr, mean follow-up 4.6 yr, 157 hip fractures), FT4 was not associated with fracture risk, whereas there was a borderline significant association between TSH (per SD decrease) and increased risk of hip fractures in men with normal TSH (0.55–4.78 mIU/L). 21 We did not detect any association between thyroid hormone levels and hip fracture risk in a previous analysis of MrOS-Sweden with shorter follow-up time (median follow-up 9.8 yr, 127 hip fractures). 22 In contrast, in the present study with longer follow-up and more incident hip fractures, we found an association between higher FT4 and increased hip fracture risk.

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