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Knowledge and practices of Iranian students (13-16 age) regarding the use of fluoride toothpaste.

BMC Oral Health · 2024 · PMC11212193 · PMID 38943104

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a decreasing trendno p-value reported
When fluoride toothpaste was introduced in the 1960s, caries only showed a decreasing trend in Sweden, while in the rest of the Western world, it took several decades to see a reduction in caries incidence.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.