Efficacy of <i>Rhamnus utilis</i> Decne. Aqueous extract in mice with acute alcoholic liver injury and metabolomic study.

In addition, the protein levels of COX-2 and iNOS in the liver tissue exhibited an increasing trend with the occurrence of acute ALD ( P < 0.01), but they were significantly reduced after administration of medium- and high-dose RDAE ( P < 0.05, P < 0.01) ( Fig. 7 A–G).

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