Fentanyl-Type Antagonist of the μ-Opioid Receptor: Important Role of Axial Chirality in the Active Conformation.

In contrast, a decreasing trend in potency was observed in 13 with 2′,6′-dimethyl (EC 50 : 4.5 nM) and 26 with 2′-ethyl,6′-methyl (EC 50 : 35 nM).

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