Sixteen of these cytokines were detected and there was an overall trend of reduced cytokine levels in CT‐1 treated compared with saline treated mice (12 out of 16 cytokines), with a significant decrease in complement component 5a (C5/C5a) ( p = 0.046; Figure 5h ), a complement molecule that promotes renal inflammation and fibrosis (Boor et al., 2007 ; Zhang et al., 2020 ). 4.
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Cardiotrophin-1 therapy reduces disease severity in a murine model of glomerular disease.
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