The effect of Huntington's disease on cognitive and physical motivation.

Specifically, the Group × Domain interaction was again significant (β = 2.36 ± 1.00, Z = 2.37, P = 0.018) and showed that the HD group were clearly less cognitively motivated than controls (χ 2 = 12.6, P = 0.0008), with group differences in the physical domain of borderline significance (χ 2 = 3.70, P = 0.054; Supplementary Table 2 ).

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In the physical domain, however, the lower motivation in the HD group relative to controls was weaker and only borderline significant when controlling for the capacity of participants to perform the task.

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