Impact of therapeutic inhibition of oncogenic cell signaling tyrosine kinase on cell metabolism: in vivo-detectable metabolic biomarkers of inhibition.

J Transl Med · 2024 · PMC11225145 · PMID 38965536

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highly significantno p-value reported

5 b), demonstrating highly significant IBR-mediated inhibition of intratumoral lactate and alanine concentrations associated with the inhibition of tumor growth.

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a decreasing trendno p-value reported

Regarding total choline, MCL-RL cells displayed a profound IBR-mediated reduction, REC-1 and JeKo-1 showed a decreasing trend, while MCL-SL exhibited no change.

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