Characterization of Unique Pathological Features of COVID-Associated Coagulopathy: Studies with AC70 hACE2 Transgenic Mice Highly Permissive to SARS-CoV-2 Infection.

Additionally, we noted the levels of hematocrit (HCT) increased significantly over time after infection with a mean count of 31.6, 35.3 (p = 0.0001) and 37.7 (p<0.0001) % at 1, 2, and 3 d.p.i., respectively, when compared to 29.2% in uninfected mice ( Fig 3K ).Thrombocyte (PLT) counts showed a decreasing trend, albeit insignificant, at the early phase of infection, that gradually rebound to thrombocytosis at the peak of infection with a mean count of 952 K/uL (p<0.0001) at day 3 p.i., when compared to those measured before infection with a mean count of 484 K/uL ( Fig 3E ).

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