A-MYB substitutes for B-MYB in activating cell cycle genes and in stimulating proliferation.

For example, the RPE-1 cell line, which displays a high A-MYB expression level, was the only among the tested cell lines in which A-MYB KD alone had a highly significant impact on Cyclin B2 expression, highlighting the importance of elevated A-MYB expression levels for its function as a B-MYB substitute.

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