<i>In vitro</i> cytoprotective and <i>in vivo</i> anti-oral mucositis effects of melatonin and its derivatives.

Melatonin could not protect against cell damage at low concentrations ( i.e ., <50 μM) but showed significant protection with an increasing trend at concentration ≥50 μM ( p < 0.05).

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Although the melatonin derivatives (BBM and EBM) showed no toxicity to cells in the cytotoxicity experiment which was performed in the presence of FBS in culture medium, a decreasing trend in the percentage of protective effects of BBM on H 2 O 2 -damaged cells was observed as concentrations increased.

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