Cellular zinc status alters chromatin accessibility and binding of p53 to DNA.

In both treatments, there was an overall trend towards reduced accessibility, with 593 regions and 334 regions having negative log 2 FoldChanges, corresponding to 73% and 64% of the differentially accessible regions for TPA and ZnCl 2 , respectively.

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Interestingly, whereas treatment with TPA led to broad changes in accessibility, suggestive of non-specific global decreases in accessibility, elevated Zn 2+ led to a smaller number of highly significant changes in accessibility in select regions, suggesting that perhaps elevation of Zn 2+ leads to changes in specific regions of chromatin ( Fig 2A ).

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