58 FAM46C expression is markedly induced during normal plasma cell differentiation; FAM46C ablation determines a highly significant, MM-specific proliferative advantage, consisting in the restriction of Ig production. 59 1p22.1-1p21.3 is the region most frequently deleted on 1p, where are mapped the genes MTF2, TMED5, RPL5 and EVI5 Among these four genes, EVI5 and RPL5 seem to be the genes most involved in MM development since the inactivation of both genes induces MM progression. 60 1p32 contains two genes, CDKN2C and FAF1 , pathogenetically relevant for MM development.
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Recent Advances in The Definition of the Molecular Alterations Occurring in Multiple Myeloma.
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