M⁶A modification in cardiovascular disease: With a focus on programmed cell death.

These pathways may be significant pathways closely related to myocardial fibrosis and can serve as important targets for diagnosing and treating myocardial fibrosis-related diseases. 130 Shao et al found that ALKBH5 post-transcriptionally activated forkhead box O3 (FOXO3) by demethylation of m 6 A via YTHDF2, enhanced cerebellar degeneration-related protein 1 antisense (CDR1as) expression, and then activated Hippo signaling pathway conducing to cardiomyocyte apoptosis in DCM mice. 131 Silencing the ALKBH5-FOXO3 m 6 A-FOXO3 mRNA-CDR1as/Hippo signaling pathway may be a promising new treatment idea for DCM.

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