Attaching Metal-Containing Moieties to β-Lactam Antibiotics: The Case of Penicillin and Cephalosporin.

Penicillin and cephalosporin derivatives containing C6–M and C7–M (M = Ir, Au) bonds have been synthesized, and the X-ray structure of the C6–Ir penam complex has been resolved. This research may be significant for the development of new active compounds targeting β-lactamase-producing bacteria.

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