We used CellphoneDB, which defines highly significant ligand‐receptor interactions between different cell populations in single‐cell data [ 34 ] and found 163 and 67 significant ligand‐receptor‐pair interactions in control and experimental groups, respectively, with 108 pairs uniquely present in the control group (Figure 4D ) (Table S2 , Supporting Information).
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Targeting Tumor Heterogeneity by Breaking a Stem Cell and Epithelial Niche Interaction Loop.
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