Biomarkers of neurodegeneration in isolated and antidepressant-related rapid eye movement sleep behavior disorder.

Besides the obvious highly significant effect of age on age at onset and at diagnosis of RBD ( p < 0.000001), we found a significant effect of treatment with antidepressants on age at diagnosis of RBD, with antiD+ patients being on average 6.6 years younger than antiD− patients, with a large effect size.

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