Progression of brain cholinergic dysfunction in patients with isolated rapid eye movement sleep behavior disorder.

A yearly reduction of 1.6% ± 0.03% from baseline to follow‐up was also observed in the substantia innominata, which was borderline significant ( p = 0.051).

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However, our cohort was very well phenotyped with polysomnography and multiple clinical assessments, making it a unique and powerful cohort, and our main findings were highly significant, thus supporting and expanding upon our baseline findings of reduced cortical cholinergic activity in iRBD.

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